Solid lipid nanoparticles and nanostructured lipid carriers as novel drug delivery systems: applications, advantages and disadvantages
نویسندگان
چکیده
منابع مشابه
Solid Lipid Nanoparticles and Nano Lipid Carriers: as Novel Solid Lipid Based Drug Carrier
Interest in lipid based drug delivery has developed over the past decade fuelled by a better understanding of the multiple roles lipids may play in enhancing oral bioavailability. Moreover, the emergence of novel excipients with acceptable regulatory and safety profiles coupled with advances in formulation technologies have greatly improved the potential for successful lipid based formulations....
متن کاملNanostructured Lipid Drug Carriers
solid lipid carriers – NLC. Particulate lipid matrices in the form of lipid pellets are known from the textbooks since many years, products are on the market (e. g. Mucosolvan retard, Boehringer-Ingelheim). After these lipid pellets as the first generation, P. Speiser developed so-called “lipid nanopellets for oral administration” in the middle of the eighties [1]. This system was not further d...
متن کاملNanostructured lipid carriers: Promising drug delivery systems for future clinics.
During the past decade, the number of studies describing nanostructured lipid carriers (NLCs)-based formulations has been dramatically increased. The raise in NLC exploitation is essentially due to defeated barriers within the technological process of lipid-based nanoparticles' formulation and increased knowledge of the underlying mechanisms of transport of NLCs via different routes of administ...
متن کاملResveratrol-loaded solid lipid nanoparticles versus nanostructured lipid carriers: evaluation of antioxidant potential for dermal applications
BACKGROUND Excessive generation of radical oxygen species (ROS) is a contributor to skin pathologies. Resveratrol (RSV) is a potent antioxidant. Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) can ensure close contact and increase the amount of drug absorbed into the skin. In this study, RSV was loaded into SLN and NLC for dermal applications. METHODS Nanoparticles wer...
متن کاملSolid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers (NLC): Occlusive Effect and Penetration Enhancement Ability
Objective: This work compares the occlusive effect and the penetration enhancement ability of solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC), through in vitro skin. Methods: SLN and NLC were prepared by high shear homogenization and characterized by size, polydispersity index, zeta potential, morphology and physical stability. Occlusive effect was assessed by an in vitr...
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ژورنال
عنوان ژورنال: Research in Pharmaceutical Sciences
سال: 2018
ISSN: 1735-5362
DOI: 10.4103/1735-5362.235156